INHIBITION OF METASTATIC HEPATOCARCINOMA BY COMBINED CHEMOTHERAPY WITH SILENCING VEGF/VEGFR2 GENES THROUGH A GALNAC-MODIFIED INTEGRATED THERAPEUTIC SYSTEM

Hepatocellular carcinoma (HCC) is a highly malignant tumor related to high mortality and is still lacking a satisfactory cure.Tumor metastasis is currently a major challenge of cancer treatment, which is highly related to angiogenesis.The vascular endothelial growth factor (VEGF)/VEGFR signaling pathway is Games thus becoming an attractive therapeu

A 60-year-old woman from Cuddalore presented with restricted neck movements, progressive difficulty in walking, and lower limb weakness, leading to bed confinement.Clinical examination revealed spastic paraparesis, brisk reflexes, and sensory deficits below the hips.Laboratory investigations indicated renal insufficiency and elevated urine fluoride

The properties of food products are the result of changes produced in raw materials as a result of process treatments.In the olive oil extraction process, these changes can be observed as differences in quality, nutritional characteristics, taste, and flavor, and are especially due to the time and temperature of the malaxation phase.These parameter

The subject of this study is one of the most interactive media networks, which is the Instagram.The study uses a descriptive approach and focuses on how Instagram turns from a media tool to a marketing tool.The study problematic consists of this question: How Instagram turns to a marketing tool, and what are the advantages and the disadvantages for

IntroductionCyclosporine A-associated neurotoxicity has been reported in up to 40% of patients and its wide range of neurological adverse effects have been reported, ranging from mild tremors to fatal leukoencephalopathy.Extrapyramidal (EP) neurotoxicity is a rare manifestation of cyclosporine.Cyclosporine-induced extrapyramidal syndrome remains a